Concepedia

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

Jung Min Han, Seung Jae Jeong, Min‐Chul Park, Gyuyoup Kim, Nam Hoon Kwon, Hoi Kyoung Kim, Sang Hoon Ha, Sung Ho Ryu, Sung‐Hoon Kim

Cell · 2012 · 802 citations · 30 references

DOIFull text

Open access

Concepts

References

30

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Yasemin Sancak, Timothy R. Peterson, Yoav D. Shaul et al. · Science · 2008 · 2.8K citations

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Yasemin Sancak, Liron Bar‐Peled, Roberto Zoncu et al. · Cell · 2010 · 2.4K citations · Full text

, , +17

Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs

Gilbert Eriani, Marc Delarue, Olivier Poch et al. · Nature · 1990 · 1.4K citations

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Regulation of TORC1 by Rag GTPases in nutrient response

Eunjung Kim, Pankuri Goraksha-Hicks, Li Li et al. · Nature Cell Biology · 2008 · 1.3K citations · Full text

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mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

Marina K. Holz, Bryan A. Ballif, Steven P. Gygi et al. · Cell · 2005 · 1.2K citations · Full text

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