The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker, Joseph M. Hendricks, Zhipeng Li, +11

Nature

Aldo-keto ReductaseBiochemistryNatural SciencesMedicineMetalloprotein +8

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Yasemin Sancak, Liron Bar‐Peled, Roberto Zoncu, +3

Cell

Protein FunctionMolecular PhysiologySignal TransductionBiochemistryAmino Acids +12

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre, Roberto Zoncu, Diego L. Medina, +10

The EMBO Journal

ChromatinSignal TransductionCell SignalingNatural SciencesMolecular Biology +8

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

Roberto Zoncu, Liron Bar‐Peled, Alejo Efeyan, +3

Science

Lysosomal Amino AcidsMolecular BiologyMtor PathwayCellular PhysiologyNutrient Signalling +18

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

Liron Bar‐Peled, Lawrence D. Schweitzer, Roberto Zoncu, +1

Cell

Molecular PhysiologySignal TransductionAllergyG Protein-coupled ReceptorImmunology +2

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

Shuyu Wang, Zhi-Yang Tsun, Rachel L. Wolfson, +14

PubMed

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

Rushika M. Perera, Svetlana Stoykova, Brandon Nicolay, +14

Nature

Cell AutophagyPancreatic CancerMedicineAutophagyLipophagy +5

Origin of GABAergic neurons in the human neocortex

Krešimir Letinić, Roberto Zoncu, Pasko Rakić

Nature

NeurophysiologyCellular NeuroscienceNeuroanatomyMedicineNeurology +7

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

Truc Nguyen, Sharon M. Louie, Joseph R. Daniele, +5

Developmental Cell

Cell AutophagyMitophagyMitochondrial BiogenesisMitochondrial FunctionStarvation-induced Autophagy +7

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Pekka Katajisto, Julia Döhla, Christine L. Chaffer, +7

Science