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A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre, Roberto Zoncu, Diego L. Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gérard Karsenty, Michel Vellard,

The EMBO Journal · 2012 · 1.9K citations · 26 references

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26

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito et al. · Science · 2011 · 3.3K citations

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Yasemin Sancak, Timothy R. Peterson, Yoav D. Shaul et al. · Science · 2008 · 2.8K citations

, , +14

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello, Michela Palmieri, Alberto di Ronza et al. · Science · 2009 · 2.5K citations

, , +17

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Yasemin Sancak, Liron Bar‐Peled, Roberto Zoncu et al. · Cell · 2010 · 2.4K citations · Full text

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang et al. · Journal of Biological Chemistry · 2009 · 1.8K citations · Full text

, , +14