International Journal of Dermatology · 1979 · 15 citations · 24 references
Life SciencesDermatologyGeneticsAutoimmunityHuman GeneticsImmunopathologyAutoimmune Skin DiseasesComplement DisordersComplement SystemCutaneous Connective Tissue DisordersImmunopathology Of SkinSystemic Lupus ErythematosusComplement Component DeficiencyComplement DeficienciesComplement DysregulationComplement GeneticsComplement In Autoimmune DiseaseComplement System AbnormalitiesComplement System DysfunctionComplement-mediated Disease
A family with hereditary deficiency of the second component of complement was studied. Three siblings were homozygous for C2 deficiency and two of them had associated skin diseases. One sister presented with idiopathic atrophoderma and the other had clinical and pathological manifestations of discoid lupus erythematosus. This is the first description of an association between idiopathic atrophoderma and C2 deficient state.
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