Concepedia

Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists

Zhaohui Yang, Xuan Li, Haikuo Ma, Jiyue Zheng, Xuechu Zhen, Xiaohu Zhang

Bioorganic & Medicinal Chemistry Letters · 2013 · 14 citations · 18 references

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18

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.4K citations

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Receptors for Purines and Pyrimidines

Geoffrey Burnstock, Alexei Verkhratsky · 2012 · 4K citations

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Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

Nicholas A. Meanwell · Journal of Medicinal Chemistry · 2011 · 2.8K citations · Full text

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Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole‐Modified Cyclic Tetrapeptides

W. Seth Horne, Christian A. Olsen, John M. Beierle et al. · Angewandte Chemie International Edition · 2009 · 152 citations · Full text

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Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

W. Cameron Black, Christopher I. Bayly, Dana Davis et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 140 citations

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