Concepedia

Amide Replacement

Amide Replacement is a medicinal chemistry strategy that involves the substitution of an amide functional group with a structurally and/or electronically similar moiety to modulate lipophilicity while preserving desired pharmacokinetic or pharmacodynamic properties.

242

Publications

9.8K

Citations

1.6K

Authors

314

Institutions

Publications per year

2017–2026

41

Parents

Publications

242

A pentapeptide from the laminin B1 chain mediates cell adhesion and binds to 67000 laminin receptor

Jeannette Graf, Roy C. Ogle, Frank A. Robey et al. · Biochemistry · 1987 · 434 citations

, , +17

Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Amit S. Kalgutkar, Alan B. Marnett, Brenda C. Crews et al. · Journal of Medicinal Chemistry · 2000 · 312 citations · Full text

, , +11

Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases.

Kelvin Stott, Jonathan M. Blackburn, P J Butler et al. · Proceedings of the National Academy of Sciences · 1995 · 223 citations

, , +14

Nonpeptidic Foldamers from Amino Acids:  Synthesis and Characterization of 1,3-Substituted Triazole Oligomers

Nicholas G. Angelo, Paramjit S. Arora · Journal of the American Chemical Society · 2005 · 220 citations

, , +13

THE ENZYMATIC FORMATION OF HYDROXAMIC ACIDS FROM GLUTAMINE AND ASPARAGINE

N. Grossowicz, Elsie Wainfan, Ernest Borek et al. · Journal of Biological Chemistry · 1950 · 188 citations · Full text

, , +14

1–5 of 242

Authors

1.6K

  1. AF
    Arno F. Spatola

    University of Louisville, United States

    4 publications · 98 citations

    4

    h-index

  2. DL
    Dale L. Boger

    Scripps Research Institute, United States

    3 publications · 232 citations

    3

    h-index

  3. KR
    Kristina Rochon

    Université de Sherbrooke, Canada

    3 publications · 89 citations

    3

    h-index

  4. DC
    David C. Rees

    King's College Hospital, United Kingdom

    3 publications · 120 citations

    3

    h-index

  5. LG
    Louis Gendron

    Université de Sherbrooke, Canada

    3 publications · 89 citations

    3

    h-index

1–5 of 1.6K

Institutions

314

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    7 h-index

    69 publications

    2.4K citations

  2. United States Military Academy

    West Point, United States

    5 h-index

    29 publications

    1.4K citations

  3. Scripps Research Institute

    San Diego, United States

    5 h-index

    19 publications

    1.3K citations

  4. Bristol-Myers Squibb (United States)

    New York, United States

    4 h-index

    55 publications

    1.2K citations

  5. University of Louisville

    Louisville, United States

    4 h-index

    6 publications

    145 citations

  6. Abbott Fund

    Chicago, United States

    3 h-index

    38 publications

    703 citations

  7. Université de Sherbrooke

    Sherbrooke, Canada

    3 h-index

    25 publications

    971 citations

  8. University of Michigan

    Ann Arbor, United States

    3 h-index

    10 publications

    628 citations

1–8 of 314

Venues

  1. Journal of Medicinal Chemistry

    55 publications · 2.6K citations

    29

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    21 publications · 430 citations

    16

    h-index

  3. Journal of the American Chemical Society

    JACS · 10 publications · 867 citations

    10

    h-index

  4. Biochemistry

    7 publications · 640 citations

    7

    h-index

  5. Organic Letters

    OL · 5 publications · 97 citations

    5

    h-index

1–5