Concepedia

Ester-to-amide Replacement

Ester-to-Amide Replacement is a molecular modification strategy in medicinal chemistry wherein an ester functional group is substituted with an amide group to enhance metabolic stability, bioavailability, or binding affinity within a bioactive compound.

23

Publications

769

Citations

160

Authors

29

Institutions

Publications per year

2017–2026

6

Parents

Publications

23

Esters, amides and substituted derivatives of cinnamic acid: synthesis, antimicrobial activity and QSAR investigations

Balasubramanian Narasimhan, Deepak P. Belsare, Devayani Pharande et al. · European Journal of Medicinal Chemistry · 2004 · 217 citations

, , +12

Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity

Adisa Tomic‐Vatic, John Eytina, James Chapman et al. · International Journal of Cancer · 2005 · 46 citations · Full text

, , +13

Ester- and amide-containing multiQACs: Exploring multicationic soft antimicrobial agents

Ryan A. Allen, Megan C. Jennings, Myles A. Mitchell et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 45 citations

, , +10

Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration

Skylar J. Ferrara, J. Matthew Meinig, Andrew T. Placzek et al. · Bioorganic & Medicinal Chemistry · 2017 · 42 citations

, , +11

.psi.[PO2-CH2N+], a new amide bond replacement: potent, slow-binding inhibition of the HIV protease

Shoji Ikeda, Jon Ashley, Peter Wirsching et al. · Journal of the American Chemical Society · 1992 · 40 citations

, , +10

1–5 of 23

Authors

160

  1. VG
    Victor G. Matassa

    IRBM Science Park, Italy

    2 publications · 56 citations

    2

    h-index

  2. PE
    Paul Eastwood

    Almirall (Spain), Spain

    2 publications · 54 citations

    2

    h-index

  3. JG
    Jacob González

    Almirall (Spain), Spain

    2 publications · 54 citations

    2

    h-index

  4. ST
    Sharon Tong

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    1 publications · 21 citations

    1

    h-index

  5. KS
    Kwang‐Sup Soh

    Seoul National University, South Korea

    1 publications · 28 citations

    1

    h-index

1–5 of 160

Institutions

29

  1. Almirall (Spain)

    Barcelona, Spain

    2 h-index

    21 publications

    573 citations

  2. University of Tasmania

    Hobart, Australia

    1 h-index

    1 publications

    28 citations

  3. Inserm

    Paris, France

    1 h-index

    3 publications

    90 citations

  4. Integral University

    Lucknow, India

    1 h-index

    6 publications

    114 citations

  5. McGill University

    Montreal, Canada

    1 h-index

    4 publications

    120 citations

  6. Universidade Federal de São Carlos

    São Carlos, Brazil

    1 h-index

    1 publications

    25 citations

  7. Universidade de São Paulo

    São Paulo, Brazil

    1 h-index

    14 publications

    350 citations

  8. RTI International

    Durham, United States

    1 h-index

    5 publications

    150 citations

1–8 of 29

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    8 publications · 205 citations

    8

    h-index

  2. Bioorganic & Medicinal Chemistry

    4 publications · 116 citations

    4

    h-index

  3. Journal of the American Chemical Society

    JACS · 2 publications · 56 citations

    3

    h-index

  4. Journal of Medicinal Chemistry

    2 publications · 49 citations

    2

    h-index

  5. Chemical and Pharmaceutical Bulletin

    1 publications · 13 citations

    1

    h-index

1–5