Victor G. Matassa

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

Frank Narjes, Konrad F. Koehler, Uwe Koch et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 181 citations · Full text

P1 Cysteine Mimetic, Biochemistry, Natural Sciences +8

Inhibition of the Hepatitis C Virus NS3/4A Protease

Stefania Di Marco, Menico Rizzi, Cinzia Volpari et al. · Journal of Biological Chemistry · 2000 · 125 citations · Full text

Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase

Vincenzo Summa, Alessia Petrocchi, Paola Pace et al. · Journal of Medicinal Chemistry · 2003 · 122 citations · Full text

Viral Replication, Viral Polymerase Structure, Molecular Biology +19

4,5-Dihydroxypyrimidine Carboxamides and <i>N</i>-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa et al. · Journal of Medicinal Chemistry · 2006 · 99 citations · Full text

Bioorganic Chemistry, Pharmacotherapy, Antiviral Drug +17

HCV NS5b RNA-Dependent RNA Polymerase Inhibitors:  From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis

Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa et al. · Journal of Medicinal Chemistry · 2004 · 91 citations · Full text

Viral Polymerase Structure, Molecular Biology, Antiviral Drug +16