Paola Pace

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli et al. · Journal of Medicinal Chemistry · 2008 · 624 citations · Full text

Antiviral Drug, Medicinal Chemistry, Antiviral Drug Development +16

Palladium-Catalyzed Cyclization of <i>o</i>-Alkynyltrifluoroacetanilides with Allyl Esters. A Regioselective Synthesis of 3-Allylindoles

Sandro Cacchi, Giancarlo Fabrizi, Paola Pace · The Journal of Organic Chemistry · 1998 · 187 citations

Cross-coupling Reaction, A Regioselective Synthesis, Engineering +11

Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase

Vincenzo Summa, Alessia Petrocchi, Paola Pace et al. · Journal of Medicinal Chemistry · 2003 · 122 citations · Full text

Viral Replication, Viral Polymerase Structure, Molecular Biology +19

4,5-Dihydroxypyrimidine Carboxamides and <i>N</i>-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa et al. · Journal of Medicinal Chemistry · 2006 · 99 citations · Full text

Bioorganic Chemistry, Pharmacotherapy, Antiviral Drug +17

HCV NS5b RNA-Dependent RNA Polymerase Inhibitors:  From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis

Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa et al. · Journal of Medicinal Chemistry · 2004 · 91 citations · Full text

Viral Polymerase Structure, Molecular Biology, Antiviral Drug +16