Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

W. Cameron Black, Christopher I. Bayly, Dana Davis, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)BiochemistryNatural SciencesMedicine +6

Biochemical Characterization ofS-Nitrosohemoglobin

Michael Wolzt, Raymond J. MacAllister, Dana Davis, +4

Journal of Biological Chemistry

Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis

Yan Lou, Xiaochun Han, A. Kuglstatter, +19

Journal of Medicinal Chemistry

Pharmaceutical ScienceTyrosine KinaseImmunologySelective Btk InhibitorsPharmacotherapy +16

Design and Synthesis of Tri-Ring P₃ Benzamide-Containing Aminonitriles as Potent, Selective, Orally Effective Inhibitors of Cathepsin K

James T. Palmer, Clifford Bryant, Dan-Xiong Wang, +30

Journal of Medicinal Chemistry

Pharmaceutical ScienceSclerostinBone ResorptionOrganic ChemistryPharmacotherapy +16

NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis

Chao He, Jennifer L. Larson‐Casey, Dana Davis, +5

JCI Insight

Lung InflammationMacrophage ActivationLipid PeroxidationImmunologyPathology +15

Cysteine-Rich and Basic Domain HIV-1 Tat Peptides Inhibit Angiogenesis and Induce Endothelial Cell Apoptosis

Haiyan Jia, Marianne Löhr, Sylvie Jezequel, +4

Biochemical and Biophysical Research Communications

InflammationAngiogenesisHuman RetrovirusImmunologyEndothelial Dysfunction +6

3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P2 elements for selectivity

Eduardo L. Setti, Dana Davis, Tobee Chung, +1

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineNatural SciencesRational Drug Design +7

Increased flux through the mevalonate pathway mediates fibrotic repair without injury

Jennifer L. Larson‐Casey, Mudit Vaid, Linlin Gu, +16

Journal of Clinical Investigation

EngineeringInflammatory Lung DiseaseLung InflammationImmunologyMechanotransduction +18

Peptides Encoded by Exon 6 of VEGF Inhibit Endothelial Cell Biological Responses and Angiogenesis Induced by VEGF

Haiyan Jia, Sylvie Jezequel, Marianne Löhr, +5

Biochemical and Biophysical Research Communications

InflammationAngiogenesisImmunologyVascular BiologyAngiogenesis Induced +8

Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling

Linlin Gu, Ranu Surolia, Jennifer L. Larson‐Casey, +5

Cell Death and Differentiation

Lung InflammationApoptosisImmunologyCell DeathPathology +16