Amyloid Protofilaments from the Calcium-binding Protein Equine Lysozyme: Formation of Ring and Linear Structures Depends on pH and Metal Ion Concentration

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti et al. · Nature · 2002 · 2.4K citations

Life Sciences, Biochemistry, Molecular Biology +17

Thioflavine T interaction with synthetic Alzheimer's disease <i>β</i>‐amyloid peptides: Detection of amyloid aggregation in solution

Harry LeVine · Protein Science · 1993 · 2.2K citations · Full text

Life Sciences, Biochemistry, Biophysics +16

Common core structure of amyloid fibrils by synchrotron X-ray diffraction 1 1Edited by F. E. Cohen

Margaret Sunde, Louise C. Serpell, Mark Bartlam et al. · Journal of Molecular Biology · 1997 · 1.7K citations

Life Sciences, Biochemistry, Biophysics +17

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Kelly A. Conway, Seung‐Jae Lee, Jean‐Christophe Rochet et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +17

Amyloid pores from pathogenic mutations

Hilal A. Lashuel, Dean M. Hartley, Benjamin M. Petre et al. · Nature · 2002 · 1.3K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14