Concepedia

Amyloid Fibrils

Amyloid Fibrils is a highly ordered, insoluble protein aggregate structure composed of misfolded polypeptides arranged in a cross-β-sheet conformation, distinguished from other protein aggregates by its characteristic fibrillar morphology, β-strand alignment perpendicular to the fibril axis, and resistance to proteolytic degradation.

11.3K

Publications

923.7K

Citations

35.9K

Authors

5.2K

Institutions

Publications per year

2017–2026

3.3K

Parents

Publications

11.3K

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Colin L. Masters, G. Simms, Nicola A. Weinman et al. · Proceedings of the National Academy of Sciences · 1985 · 4.4K citations · Full text

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

, , +14

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4.1K citations

, , +17

Consort 2010 statement: extension to cluster randomised trials

Marion Campbell, Gilda Piaggio, Diana R Elbourne et al. · BMJ · 2012 · 3.6K citations · Full text

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Diffusible, nonfibrillar ligands derived from Aβ <sub>1–42</sub> are potent central nervous system neurotoxins

Mary P. Lambert, Avlin Barlow, Brett A. Chromy et al. · Proceedings of the National Academy of Sciences · 1998 · 3.5K citations · Full text

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1–5 of 11.3K

Authors

35.9K

  1. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    179 publications · 30.4K citations

    94

    h-index

  2. RM
    Raffaele Mezzenga

    ETH Zurich, Switzerland

    127 publications · 11.7K citations

    61

    h-index

  3. DE
    David Eisenberg

    University of California, Los Angeles, United States

    84 publications · 18.7K citations

    61

    h-index

  4. PW
    Per Westermark

    Uppsala University, Sweden

    113 publications · 13.4K citations

    54

    h-index

  5. TP
    Tuomas P. J. Knowles

    University of Cambridge, United Kingdom

    94 publications · 13K citations

    53

    h-index

1–5 of 35.9K

Institutions

5.2K

  1. University of Cambridge

    Cambridge, United Kingdom

    105 h-index

    1.3K publications

    162.5K citations

  2. Harvard University

    Cambridge, United States

    101 h-index

    806 publications

    191.2K citations

  3. Brigham and Women's Hospital

    Boston, United States

    87 h-index

    506 publications

    140K citations

  4. University of California, Los Angeles

    Los Angeles, United States

    84 h-index

    723 publications

    122.5K citations

  5. National Institutes of Health

    Bethesda, United States

    84 h-index

    630 publications

    105.5K citations

  6. ETH Zurich

    Zurich, Switzerland

    75 h-index

    849 publications

    89.3K citations

  7. New York University

    New York, United States

    73 h-index

    555 publications

    72.7K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    70 h-index

    480 publications

    107K citations

1–8 of 5.2K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 409 publications · 107K citations

    179

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  2. Journal of Biological Chemistry

    JBC · 546 publications · 72.3K citations

    140

    h-index

  3. Biochemistry

    483 publications · 48.6K citations

    117

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  4. Journal of the American Chemical Society

    JACS · 291 publications · 29.4K citations

    105

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  5. Journal of Molecular Biology

    JMB · 270 publications · 29.7K citations

    98

    h-index

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