Association between AKT/mTOR signalling pathway and malignancy grade of human gliomas

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

Life Sciences, Cell Biology, Molecular Biology +6

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

Eric C. Holland, Joseph Celestino, Chengkai Dai et al. · Nature Genetics · 2000 · 903 citations

Medicine, Cancer Biology, Oncology +12

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

Tim Cloughesy, Koji Yoshimoto, Phioanh L. Nghiemphu et al. · PLoS Medicine · 2008 · 591 citations · Full text

Medicine, Oncology, Pharmacology +14

mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor

Janine Masri, Andrew Bernath, Jheralyn Martin et al. · Cancer Research · 2007 · 255 citations

Medicine, Oncology, Pharmacology +13

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral‐Barza et al. · Cancer Research · 2010 · 208 citations · Full text

Medicine, Oncology, Pharmacology +14