Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

Haruhiko Kouhara, Yaron R. Hadari, Taly R. Spivak-Kroizman et al. · Cell · 1997 · 871 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

A constitutively active epidermal growth factor receptor cooperates with disruption of G₁ cell-cycle arrest pathways to induce glioma-like lesions in mice

Eric C. Holland, Wendy P. Hively, Ronald A. DePinho et al. · Genes & Development · 1998 · 561 citations · Full text

Medicine, Molecular Biology, Oncology +17

Proliferation of human malignant astrocytomas is dependent on Ras activation

Abhijit Guha, Matthias M. Feldkamp, Nelson C. Lau et al. · Oncogene · 1997 · 340 citations

Medicine, Cell Biology, Oncology +14

The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.

Jing Li, Laura J. Simpson, Michelle Takahashi et al. · PubMed · 1998 · 311 citations

Life Sciences, Cancer Biology, Oncology +17

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

Eric C. Holland, Harold Varmus · Proceedings of the National Academy of Sciences · 1998 · 308 citations

Medicine, Genetics, Molecular Biology +13