Concepedia

Ras Pathway Activation

RAS Pathway Activation is a molecular signaling event characterized by the induction of downstream signal transduction cascades through the GTP-bound active state of RAS proteins, distinguishing it from other oncogenic mechanisms by its specific reliance on RAS family GTPases to propagate cellular proliferation and survival signals.

1.9K

Publications

141.2K

Citations

12.1K

Authors

2.2K

Institutions

Publications per year

2017–2026

332

Parents

Publications

1.9K

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

Anne‐Pierre Morel, Marjory Lièvre, Clémence Thomas et al. · PLoS ONE · 2008 · 1.6K citations · Full text

, , +17

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

David D. Schlaepfer, Steven K. Hanks, Tony Hunter et al. · Nature · 1994 · 1.6K citations

, , +16

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

Maria Rozakis-Adcock, Ross T. Fernley, John D. Wade et al. · Nature · 1993 · 1K citations

, , +17

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

George A. Martin, David Viskoohil, Gideon Bollag et al. · Cell · 1990 · 1K citations

, , +14

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Maria Rozakis-Adcock, Jane McGlade, Geraldine Mbamalu et al. · Nature · 1992 · 993 citations

, , +15

1–5 of 1.9K

Authors

12.1K

  1. YK
    Yoel Kloog

    Tel Aviv University, Israel

    16 publications · 1K citations

    15

    h-index

  2. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    17 publications · 1.8K citations

    15

    h-index

  3. FM
    Frank McCormick

    University of California, San Francisco, United States

    15 publications · 2.9K citations

    14

    h-index

  4. JD
    Julian Downward

    The Honourable Society of Lincoln's Inn, United Kingdom

    12 publications · 2.3K citations

    12

    h-index

  5. MZ
    Martin Zenker

    University Hospital Magdeburg, Germany

    10 publications · 567 citations

    10

    h-index

1–5 of 12.1K

Institutions

2.2K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    39 h-index

    134 publications

    31.2K citations

  2. Harvard University

    Cambridge, United States

    39 h-index

    197 publications

    20.4K citations

  3. University of California, San Francisco

    San Francisco, United States

    31 h-index

    157 publications

    16.3K citations

  4. Inserm

    Paris, France

    29 h-index

    247 publications

    27.2K citations

  5. National Cancer Institute

    Bethesda, United States

    28 h-index

    142 publications

    16K citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    25 h-index

    151 publications

    29.1K citations

  7. University of Toronto

    Toronto, Canada

    23 h-index

    71 publications

    8.4K citations

  8. National Institutes of Health

    Bethesda, United States

    22 h-index

    115 publications

    15.5K citations

1–8 of 2.2K

Venues

  1. Journal of Biological Chemistry

    JBC · 152 publications · 14.7K citations

    73

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  2. Molecular and Cellular Biology

    MCB · 71 publications · 6.2K citations

    47

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 54 publications · 7.2K citations

    46

    h-index

  4. Oncogene

    73 publications · 5.8K citations

    43

    h-index

  5. PubMed

    Repository · 103 publications · 5.2K citations

    42

    h-index

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