Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Improved retroviral vectors for gene transfer and expression.

A. Dusty Miller, G J Rosman · PubMed · 1989 · 2K citations · Full text

High-titer Virus Stocks, Viral Replication, Murine Retrovirus-based Vectors +14

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Eve J. Lowenstein, Roger J. Daly, Andreas Batzer et al. · Cell · 1992 · 1.6K citations · Full text

The trk proto-oncogene encodes a receptor for nerve growth factor

Rüdiger Klein, Venkata Nanduri, Edward C. O’Rourke et al. · Cell · 1991 · 1.4K citations

Signal Transduction, Molecular Physiology, Developmental Biology +9

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

Giuliana Pelicci, Luisa Lanfrancone, F Grignani et al. · Cell · 1992 · 1.3K citations

Signal Transduction, Signaling Pathway, Protein Expression +11

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

Barbara L. Hempstead, Dionisio Martín‐Zanca, David R. Kaplan et al. · Nature · 1991 · 1.2K citations

Trk Proto-oncogene, Signal Transduction, Low-affinity Ngf Receptor +11