Concepedia

Sh2-binding Motif

An SH2-Binding Motif is a short amino acid sequence that serves as a protein interaction module by specifically binding to Src homology 2 (SH2) domains in signaling proteins, thereby mediating intracellular signal transduction events.

455

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43.2K

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2.3K

Authors

579

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2017–2026

37

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Publications

455

SH2 domains recognize specific phosphopeptide sequences

Cell · 1993 · 2.7K citations

, , +14

A new protein containing an SH2 domain that inhibits JAK kinases

Takaho A. Endo, Masaaki Masuhara, Masahiro Yokouchi et al. · Nature · 1997 · 1.4K citations

, , +16

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

Giuliana Pelicci, Luisa Lanfrancone, F Grignani et al. · Cell · 1992 · 1.3K citations

, , +14

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Maria Rozakis-Adcock, Jane McGlade, Geraldine Mbamalu et al. · Nature · 1992 · 993 citations

, , +15

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

Zhou Songyang, Steven E. Shoelson, Jane McGlade et al. · Molecular and Cellular Biology · 1994 · 878 citations · Full text

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1–5 of 455

Authors

2.3K

  1. TP
    Tony Pawson

    Mount Sinai Hospital, Canada

    25 publications · 6.1K citations

    22

    h-index

  2. SE
    Steven E. Shoelson

    Joslin Diabetes Center, United States

    11 publications · 2K citations

    11

    h-index

  3. SS
    Shawn S.‐C. Li

    Western University, Canada

    9 publications · 537 citations

    9

    h-index

  4. PP
    Peter P. Roller

    National Cancer Institute, United States

    9 publications · 516 citations

    9

    h-index

  5. GG
    Gerald Gish

    Lunenfeld-Tanenbaum Research Institute, Canada

    9 publications · 868 citations

    9

    h-index

1–5 of 2.3K

Institutions

579

  1. Harvard University

    Cambridge, United States

    31 h-index

    131 publications

    26.2K citations

  2. University of Toronto

    Toronto, Canada

    23 h-index

    79 publications

    6.3K citations

  3. Mount Sinai Hospital

    Toronto, Canada

    22 h-index

    93 publications

    18.5K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    21 h-index

    40 publications

    8.3K citations

  5. Lunenfeld-Tanenbaum Research Institute

    Toronto, Canada

    19 h-index

    70 publications

    11.7K citations

  6. National Institutes of Health

    Bethesda, United States

    19 h-index

    75 publications

    5.8K citations

  7. National Cancer Institute

    Bethesda, United States

    16 h-index

    62 publications

    3.3K citations

  8. Dana-Farber Cancer Institute

    Boston, United States

    15 h-index

    58 publications

    8.7K citations

1–8 of 579

Venues

  1. Journal of Biological Chemistry

    JBC · 71 publications · 5.6K citations

    41

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  2. Molecular and Cellular Biology

    MCB · 27 publications · 3.9K citations

    25

    h-index

  3. Journal of Molecular Biology

    JMB · 20 publications · 1.3K citations

    18

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 19 publications · 3.2K citations

    18

    h-index

  5. Oncogene

    16 publications · 791 citations

    15

    h-index

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