Concepedia

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators

Lei Zhang, Bruce N. Rogers, Allen J. Duplantier, Stanley F. McHardy, Ivan Efremov, H. BERKE, Weimin Qian, Andy Q. Zhang, Noha Maklad, John Candler,

Bioorganic & Medicinal Chemistry Letters · 2008 · 24 citations · 10 references

DOIFull text

Open access

Concepts

References

10

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

Sandeep T. Patil, Lu Zhang, Ferenc Martényi et al. · Nature Medicine · 2007 · 1K citations

, , +12

Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795

Ann E. Kingston, Michael J. O’Neill, Amy G.M Lam et al. · European Journal of Pharmacology · 1999 · 100 citations

, , +12

LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats

Jolanta Konieczny, Krystyna Ossowska, S. Wolfarth et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 1998 · 96 citations

, , +12

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

Will Spooren, F. Gasparini, Herman van der Putten et al. · European Journal of Pharmacology · 2000 · 95 citations

, , +12

Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing

Carrie K. Jones, Elizabeth L. Eberle, Stephen C. Peters et al. · Neuropharmacology · 2005 · 86 citations

, , +15