Lei Zhang

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Lei Zhang, Anabella Villalobos, Elizabeth M. Beck et al. · Journal of Medicinal Chemistry · 2013 · 203 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

(−)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer׳s disease model mice by upregulating neprilysin expression

Xiang Chang, Cuiping Rong, Yunbo Chen et al. · Experimental Cell Research · 2015 · 121 citations

Life Sciences, Neuroscience, Pharmacology +14

Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1<i>H</i>)-one Series of Potent<scp>d</scp>-Amino Acid Oxidase (DAAO) Inhibitors

Allen J. Duplantier, Stacey L. Becker, Michael J. Bohanon et al. · Journal of Medicinal Chemistry · 2009 · 110 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Muscarinic Acetylcholine Receptor Regulation of TRP6 Ca2+ Channel Isoforms

Lei Zhang, David Saffen · Journal of Biological Chemistry · 2001 · 99 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Jennifer E. Davoren, Che‐Wah Lee, Michelle R. Garnsey et al. · Journal of Medicinal Chemistry · 2016 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17