Concepedia

Complement 5a Receptor Mediates Angiotensin II–Induced Cardiac Inflammation and Remodeling

Congcong Zhang, Yulin Li, Chunxiao Wang, Yina Wu, Wei Cui, Takashi Miwa, Sayaka Sato, Huihua Li, Wen‐Chao Song, Jie Du

Arteriosclerosis Thrombosis and Vascular Biology · 2014 · 74 citations · 24 references

DOIFull text

Open access

Abstract

Complement is activated in hypertensive hearts, and the C5aR signaling pathway on blood monocytes/macrophages plays a pathological role in Ang II-induced cardiac inflammation and remodeling. Therapeutic inhibition of complement may protect patients from hypertension-related heart injury.

References

24

Generation of C5a in the absence of C3: a new complement activation pathway

Markus Huber‐Lang, J. Vidya Sarma, Firas S. Zetoune et al. · Nature Medicine · 2006 · 964 citations

, , +5

Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes.

M. Edward Medof, Taroh Kinoshita, Victor Nussenzweig · The Journal of Experimental Medicine · 1984 · 560 citations · Full text

, , +21

Platelet activation leads to activation and propagation of the complement system

Ian Del Conde, Miguel A. Crúz, Hui Zhang et al. · The Journal of Experimental Medicine · 2005 · 389 citations · Full text

, , +19

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

Jin Wu, You‐Qiang Wu, Daniel Ricklin et al. · Nature Immunology · 2009 · 321 citations · Full text

, , +8

Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II

Feifei Ma, Yulin Li, Lixin Jia et al. · PLoS ONE · 2012 · 258 citations · Full text

, , +19