Concepedia

Development of a Hybrid Physiologically Based Pharmacokinetic Model with Drug‐Specific Scaling Factors in Rat to Improve Prediction of Human Pharmacokinetics

Hiroyuki Sayama, Hiroshi Komura, Motohiro Kogayu, Masahiro Iwaki

Journal of Pharmaceutical Sciences · 2013 · 15 citations · 26 references

DOI

Concepts

References

26

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Trudy Rodgers, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2006 · 919 citations

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Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Trudy Rodgers, David E. Leahy, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2005 · 765 citations

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Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

Ping Zhao, L Zhang, Joseph A. Grillo et al. · Clinical Pharmacology & Therapeutics · 2010 · 507 citations

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A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

Patrick Poulin, Frank‐Peter Theil · Journal of Pharmaceutical Sciences · 2000 · 419 citations

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The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 399 citations