Hiroshi Komura

A selective novel low‐molecular‐weight inhibitor of I<i>κ</i>B kinase‐<i>β</i> (IKK‐<i>β</i>) prevents pulmonary inflammation and shows broad anti‐inflammatory activity

Karl Ziegelbauer, Florian Gantner, Nicholas W. Lukacs et al. · British Journal of Pharmacology · 2005 · 146 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Synthesis and structure–activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents

Toshiki Murata, Mitsuyuki Shimada, Sachiko Sakakibara et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 121 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients

Hiroyuki Sayama, Hiroaki Takubo, Hiroshi Komura et al. · The AAPS Journal · 2014 · 55 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4

Hiromi Okigami, Keisuke Takeshita, Masaomi Tajimi et al. · European Journal of Pharmacology · 2006 · 42 citations

Medicine, Immunology, Pharmacology +14

Development of an <i>In Silico</i> Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration

Reiko Watanabe, Tsuyoshi Esaki, Rikiya Ohashi et al. · Journal of Medicinal Chemistry · 2021 · 39 citations

Pharmacy, Pharmacokinetics, Pharmacology +17