Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1

Toshiki Murata, Mitsuyuki Shimada, Sachiko Sakakibara, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyDrug TargetMedicineRational Drug DesignPharmacotherapy +6

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

Ichiro Kawashima, Jun Ohsumi, Katsuko Mita-Honjo, +5

FEBS Letters

Synthesis and structure–activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents

Toshiki Murata, Mitsuyuki Shimada, Sachiko Sakakibara, +14

Bioorganic & Medicinal Chemistry Letters

InflammationMedicinal ChemistryAnti-inflammatoryMedicineImmunology +9

Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells.

Jun Ohsumi, Sachiko Sakakibara, Junna Yamaguchi, +5

Endocrinology

ImmunologyPathologyInsulin SignalingInflammationMetabolic Syndrome +19

Molecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones

Minoru Oguchi, Kunio Wada, Hidehito Honma, +8

Journal of Medicinal Chemistry

Imidazopyridine Thiazolidine-2,4-dionesEngineeringBiochemistryMedicineDrug Discovery +12

Synthesis and structure–activity relationships of novel IKK-β inhibitors. Part 2: Improvement of in vitro activity

Toshiki Murata, Mitsuyuki Shimada, Hiroshi KADONO, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +10

Adipogenesis inhibitory factor A novel inhibitory regulator of adipose conversion in bone marrow

Jun Ohsumi, Kenji Miyadai, Ichiro Kawashima, +4

FEBS Letters

Detection of Dystrophin Dp71 in Human Skeletal Muscle Using an Automated Capillary Western Assay System

Tatsuya Kawaguchi, Emma Tabe Eko Niba, Abdul Qawee Rani, +11

International Journal of Molecular Sciences

Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats

Hiroyuki Nagase, Yasuo Nagasawa, Yuki Tachida, +5

Osteoarthritis and Cartilage

InflammationDeiodinase 2Musculoskeletal ResearchBone Morphogenic ProteinCartilage Destruction +8

A New Efficient Synthesis of Nicotianamine and 2'-Deoxymugineic Acid

Takayuki Shioiri, Naoko Irako, Sachiko Sakakibara, +2

Heterocycles

New Efficient SynthesisBiosynthesisBioorganic ChemistryInvestigated.both NicotianamineBiochemistry +12