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Publication | Open Access

Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

DOIFull Paper Access

176

Citations

54

References

2014

Year

Savita Sankar, Emily R. Theisen, Jared Bearss, Timothy Mulvihill, Laura Hoffman, Venkataswamy Sorna, Mary C. Beckerle, Sunil Sharma, Stephen L. Lessnick
Clinical Cancer Research

Abstract

These data support epigenetic modulation with HCI2509 as a therapeutic strategy for Ewing sarcoma, and highlight a critical dual role for LSD1 in the oncogenic transcriptional activity of EWS/ETS proteins.

References

YearCitations

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