Concepedia

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

Piet H. van der Graaf, Neil Benson

Pharmaceutical Research · 2011 · 242 citations · 7 references

DOI

Concepts

References

7

Can Animal Models of Disease Reliably Inform Human Studies?

H. Bart van der Worp, David W. Howells, Emily S. Sena et al. · PLoS Medicine · 2010 · 1.3K citations · Full text

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Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling—A New Classification of Biomarkers

Meindert Danhof, Gunnar Alván, Svein G. Dahl et al. · Pharmaceutical Research · 2005 · 163 citations

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Concepts and Challenges in Quantitative Pharmacology and Model-Based Drug Development

Liping Zhang, Marc Pfister, Bernd Meibohm · The AAPS Journal · 2008 · 92 citations · Full text

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Pharmacometrics: The Science of Quantitative Pharmacology

Andreas Krause · Journal of the American Statistical Association · 2008 · 67 citations

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Mathematical analysis of the pharmacokinetic–pharmacodynamic (PKPD) behaviour of monoclonal antibodies: Predicting in vivo potency

Philip J. Aston, Gianne Derks, Adewale Raji et al. · Journal of Theoretical Biology · 2011 · 50 citations · Full text

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