Piet H. van der Graaf

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

Paul Morgan, Piet H. van der Graaf, John Arrowsmith et al. · Drug Discovery Today · 2011 · 677 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

Piet H. van der Graaf, Neil Benson · Pharmaceutical Research · 2011 · 242 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Peter A. Milligan, Marcy Brown, B Marchant et al. · Clinical Pharmacology & Therapeutics · 2013 · 236 citations

Medicine, Pharmacology, Clinical Pharmacology +10

Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends

Thomas J. Snowden, Piet H. van der Graaf, Marcus J. Tindall · Bulletin of Mathematical Biology · 2017 · 158 citations · Full text

Engineering, Systems Biology, Biological Systems Modeling +13

Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach

Alison Betts, Anne Keunecke, Tamara J. van Steeg et al. · mAbs · 2018 · 108 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +17