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Evaluation of Approach to Predict the Contribution of Multiple Cytochrome P450s in Drug Metabolism Using Relative Activity Factor: Effects of the Differences in Expression Levels of NADPH–Cytochrome P450 Reductase and Cytochrome b5 in the Expression System and the Differences in the Marker Activities

Miki Nakajima, Kazuhiro Tane, Sumika Nakamura, Noriaki Shimada, Hiroshi Yamazaki, Tsuyoshi Yokoi

Journal of Pharmaceutical Sciences · 2002 · 49 citations · 22 references

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References

22

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 535 citations

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Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

David J. Waxman, C Attisano, F. Peter Guengerich et al. · Archives of Biochemistry and Biophysics · 1988 · 415 citations

, , +11

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

Jack Gorski, Stephen D. Hall, D. I. Jones et al. · Biochemical Pharmacology · 1994 · 397 citations

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Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

, , +17

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

Linda M. Distlerath, P.E.B. Reilly, M V Martin et al. · Journal of Biological Chemistry · 1985 · 318 citations · Full text

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