L J Yu

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

Medicine, Biochemistry, Pharmacology +17

P450 enzyme expression patterns in the NCI human tumor cell line panel.

L J Yu, J M De Matias, Dominic A. Scudiero et al. · PubMed · 2001 · 86 citations

Medicine, Oncology, Pharmacology +17

In Vivo Modulation of Alternative Pathways of P-450-Catalyzed Cyclophosphamide Metabolism: Impact on Pharmacokinetics and Antitumor Activity

L J Yu, Pernille Drewes, Katja Gustafsson et al. · Journal of Pharmacology and Experimental Therapeutics · 1999 · 81 citations

Medicine, Pharmacokinetics, Pharmacology +17

Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.

Lin Chen, L J Yu, David J. Waxman · PubMed · 1997 · 77 citations

Medicine, Oncology, Pharmacology +17

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

Michael P. DeNinno, Melissa P. Andrews, Andrew Bell et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8