The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

N.K. Terrett, Andrew Bell, David Brown et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 606 citations

Medicine, Pharmacology, Pharmacotherapy +12

Isolation and Characterization of PDE9A, a Novel Human cGMP-specific Phosphodiesterase

Douglas A. Fisher, James F. Smith, Joann S. Pillar et al. · Journal of Biological Chemistry · 1998 · 342 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Enantioselective alkylation of ketones via chiral, nonracemic lithioenamines. An asymmetric synthesis of .alpha.-alkyl and .alpha.,.alpha.'-dialkyl cyclic ketones

A. I. MEYERS, Donald R. Williams, Gary W. Erickson et al. · Journal of the American Chemical Society · 1981 · 159 citations

Natural Sciences, Chemistry, Catalysis +10

Characterization of the First Potent and Selective PDE9 Inhibitor Using a cGMP Reporter Cell Line

Frank Wunder, Adrian Tersteegen, Annegret Rebmann et al. · Molecular Pharmacology · 2005 · 146 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Update on Phosphodiesterase (PDE) Isoenzymes as Pharmacologic Targets in Urology: Present and Future

Stefan Ückert, Petter Hedlund, Karl‐Erik Andersson et al. · European Urology · 2006 · 98 citations

Medicine, Pharmacology, Urology +7