Concepedia

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi, David J. Waxman

Drug Metabolism and Disposition · 1999 · 319 citations · 40 references

DOI

Concepts

References

40

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

, , +15

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Deborah J. Newton, R W Wang, Anthony Y.H. Lu · Drug Metabolism and Disposition · 1995 · 606 citations

, , +17

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

Thomas K. H. Chang, Georg F. Weber, Charles L. Crespi et al. · PubMed · 1993 · 550 citations

, , +16

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

Allan E. Rettie, Larry C. Wienkers, Frank J. Gonzalez et al. · Pharmacogenetics · 1994 · 493 citations

, , +10

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

Toshifumi Aoyama, Saki Yamano, David J. Waxman et al. · Journal of Biological Chemistry · 1989 · 482 citations · Full text

, , +12