Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

The P450 Gene Superfamily: Recommended Nomenclature

Daniel W. Nebert, Milton Adesnik, Minor J. Coon et al. · DNA · 1987 · 815 citations

Life Sciences, Genetics, Molecular Genetics +15

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

Frank J. Gonzalez, Radek C. Skodat, Shioko Kimura et al. · Nature · 1988 · 718 citations

Life Sciences, Genetics, Molecular Genetics +12

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

David J. Waxman, Ghazi A. Dannan, F. Peter Guengerich · Biochemistry · 1985 · 599 citations

Medicine, Biochemistry, Endocrinology +11

Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver.

David J. Waxman, Albert I. Ko, Christopher T. Walsh · Journal of Biological Chemistry · 1983 · 393 citations · Full text

Medicine, Biochemistry, Pharmacology +17