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MedicineOncologyPharmacologyCancer PharmacologyChemotherapyMolecular OncologyChemotherapy ResistanceDrug ResistanceMultidrug ResistancePharmacodynamics Of Anticancer AgentsPharmacodynamics Of Anticancer DrugsTherapeutic ResistanceAnticancer Drug ResistanceCancer Cell Proliferation InhibitionDrug Resistance ModulationOvercoming Multidrug ResistanceResistance To Cell Cycle-targeted DrugsResistance To Targeted TherapySorafenib Therapy
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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
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Inhibition of Macroautophagy Triggers Apoptosis
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