Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Life Sciences, Genetics, Molecular Genetics +16

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature · 1987 · 4.6K citations

Life Sciences, Molecular Biology, Neuroscience +14

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Fred Esch, Pamela S. Keim, Eric C. Beattie et al. · Science · 1990 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +17

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

Andreas Weidemann, Gerhard König, Dirk Bunke et al. · Cell · 1989 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +12

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

Rudolph E. Tanzi, Andrea I. McClatchey, Edward D. Lamperti et al. · Nature · 1988 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +14