Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Myunggon Ko, Yun Huang, A. Jankowska, +12

Nature

Hematological MalignancyTumor BiologyMutant Tet2Oncogenic AgentMedicine +7

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

Rudolph E. Tanzi, Andrea I. McClatchey, Edward D. Lamperti, +3

Nature

Alzheimer's DiseaseProtein FoldingDementiaMedicineProtease Inhibitor Domain +10

doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling Protein

Joseph G. Gleeson, Kristina M. Allen, Jeremy W. Fox, +8

Cell

Brain-specific Gene MutatedDevelopmental BiologyGenetic DisorderNeuroanatomyGenetics +9

Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia

Jeremy W. Fox, Edward D. Lamperti, Yaman Z. Ekşioğlu, +10

Neuron

Developmental BiologyMolecular NeuroscienceNeurogenomicsNeurophysiologyNeuroanatomy +12

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

Gustavo Martínez, Renata M. Pereira, Tarmo Äijö, +13

Immunity

Transcriptional RegulationSignal TransductionCell RegulationAdaptive Immune SystemImmunology +7

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

Myunggon Ko, Hozefa S. Bandukwala, Jungeun An, +7

Proceedings of the National Academy of Sciences

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

Yousang Gwack, Sonal Srikanth, Masatsugu Oh‐hora, +10

Molecular and Cellular Biology

ImmunologyImmunologic MechanismCellular PhysiologyOrai1 GeneInflammation +17

Selective inhibition of CD4 ⁺ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

Hozefa S. Bandukwala, John D Gagnon, Susan Togher, +11

Proceedings of the National Academy of Sciences

NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network

Sankar Bhattacharyya, Jolly Deb, Amiya K. Patra, +18

The Journal of Experimental Medicine

Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing

K. Mark Ansel, William A. Pastor, Nicola Rath, +12

Nature Structural & Molecular Biology

Natural SciencesRna BiologyMolecular BiologyRrna ProcessingMouse Eri1 +6