Concepedia

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

Ji‐Hong Lim, Yoon-Mi Lee, Yang‐Sook Chun, Junjie Chen, Ja‐Eun Kim, Jong‐Wan Park

Molecular Cell · 2010 · 762 citations · 34 references

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34

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Jung‐whan Kim, Irina Tchernyshyov, Gregg L. Semenza et al. · Cell Metabolism · 2006 · 3.9K citations · Full text

, , +17

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Heidi A. Tissenbaum, Leonard Guarente · Nature · 2001 · 1.9K citations

, , +10

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Jason G. Wood, Blanka Rogina, Siva Lavu et al. · Nature · 2004 · 1.9K citations

, , +16