HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Jung‐whan Kim, Irina Tchernyshyov, Gregg L. Semenza, +1

Cell Metabolism

Reductive StressSignal TransductionBiochemistryRedox RegulatorMedicine +9

HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

Ryo Fukuda, Huafeng Zhang, Jung‐whan Kim, +3

Cell

Redox SignalingBiochemistryRedox RegulatorNatural SciencesPhysiology +11

Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1

Jung‐whan Kim, Ping Gao, Yen-Chun Liu, +2

Molecular and Cellular Biology

Inducible MycPathologyMetabolic RemodelingCancer BiologyTumor Biology +19

Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

Li Feng, Yunyue Wang, Karen Zeller, +7

Molecular and Cellular Biology

Reductive StressMitophagySystems BiologyMitochondrial BiogenesisMitochondrial Function +12

Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis

Norihiko Takeda, Ellen L O'Dea, Andrew L. Doedens, +7

Genes & Development

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

Yun Sok Lee, Jung‐whan Kim, Olivia Osborne, +10

Cell

Insulin ResistanceMetabolic SyndromeObesityCausing InflammationMetabolic Disorder +10

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Surendra K. Shukla, Vinee Purohit, Kamiya Mehla, +34

Cancer Cell

Tumor BiologyImpart Gemcitabine ResistancePancreatic CancerOncogenic AgentMedicine +5

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression

Jonathan Chou, Jeffrey Lin, Audrey Brenot, +3

Nature Cell Biology

Tumor BiologyOncologyMedicineMicrorna-29b ExpressionTumour Microenvironment +7

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, +21

Nature Communications

Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays

Jung‐whan Kim, Karen Zeller, Yunyue Wang, +4

Molecular and Cellular Biology

GeneticsGene CharacterizationGene Regulatory NetworkGenomicsTumor Biology +20