Concepedia

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Heidi A. Tissenbaum, Leonard Guarente

Nature · 2001 · 1.9K citations · 26 references

DOI

Concepts

References

26

THE GENETICS OF <i>CAENORHABDITIS ELEGANS</i>

Sydney Brenner · Genetics · 1974 · 15.5K citations · Full text

, , +14

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

, , +16

A C. elegans mutant that lives twice as long as wild type

Cynthia Kenyon, Jean Chang, Erin Gensch et al. · Nature · 1993 · 3.4K citations

, , +6

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

C C Mello, James M. Kramer, Dan T. Stinchcomb et al. · The EMBO Journal · 1991 · 3.2K citations · Full text

, , +8

<i>daf-2</i> , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in <i>Caenorhabditis elegans</i>

Koutarou D. Kimura, Heidi A. Tissenbaum, Yanxia Liu et al. · Science · 1997 · 2.3K citations

, , +17