Concepedia

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Michel Weïwer, Joshua A. Bittker, Timothy A. Lewis, Wan Seok Yang, Lawrence MacPherson, Sivaraman Dandapani, Michelle Palmer, Brent R. Stockwell, Stuart L. Schreiber, Benito Muñoz

Bioorganic & Medicinal Chemistry Letters · 2011 · 238 citations · 14 references

DOI

Concepts

References

14

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, Pablo Tamayo, Jesse S. Boehm et al. · Nature · 2009 · 4.2K citations · Full text

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Creation of human tumour cells with defined genetic elements

William C. Hahn, Christopher M. Counter, Ante S. Lundberg et al. · Nature · 1999 · 2.3K citations

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Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

Wan Seok Yang, Brent R. Stockwell · Chemistry & Biology · 2008 · 1.9K citations · Full text

, , +14

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Sonam Dolma, Stephen L. Lessnick, William C. Hahn et al. · Cancer Cell · 2003 · 1.4K citations · Full text

, , +13

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

Ji Luo, Michael J. Emanuele, Danan Li et al. · Cell · 2009 · 1K citations

, , +12