Concepedia

Synthesis and evaluation of functionalized isoindigos as antiproliferative agents

Xi Kai Wee, Wee Kiang Yeo, Bing Zhang, V.B.C. Tan, Kian Meng Lim, T.E. Tay, Mei‐Lin Go

Bioorganic & Medicinal Chemistry · 2009 · 87 citations · 26 references

DOI

Concepts

References

26

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

, , +16

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

, , +15

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber et al. · Nature Biotechnology · 2005 · 1.9K citations · Full text

, , +12

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Philip D. Jeffrey, Alicia A. Russo, Kornélia Polyák et al. · Nature · 1995 · 1.4K citations

, , +9

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

Ralph Hoessel, Sophie Leclerc, Jane Endicott et al. · Nature Cell Biology · 1999 · 814 citations

, , +13