William Biggs

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber et al. · Nature Biotechnology · 2005 · 1.9K citations · Full text

Molecular Docking, Drug Target, Clinical Kinase Inhibitors +4

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

Karen Yamamoto, G. González, William Biggs et al. · Nature · 1988 · 1.3K citations

Transcriptional Regulation, Signal Transduction, Nuclear Factor Creb +5

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

William Biggs, Jill Meisenhelder, Tony Hunter et al. · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations · Full text

Molecular Biology, Signaling Pathway, Cell Regulation +16

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

Rohit Loomba, Victor Seguritan, Weizhong Li et al. · Cell Metabolism · 2017 · 1.1K citations · Full text

Dysbiosis, Hepatology, Medicine +12

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

Gustavo González, Karen Yamamoto, Wolfgang Fischer et al. · Nature · 1989 · 916 citations

Signal Transduction, Natural Sciences, Transcription Regulation +10