Concepedia

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

Supriya K. Saha, Christine A. Parachoniak, Krishna S. Ghanta, Julien Fitamant, Kenneth N. Ross, Mortada S. Najem, Sushma Gurumurthy, Esra A. Akbay, Daniela Sia, Helena Cornellà,

Nature · 2014 · 469 citations · 30 references

DOI

Concepts

References

30

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

New England Journal of Medicine · 2013 · 5.2K citations · Full text

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4.1K citations · Full text

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Wei Xu, Hui Yang, Ying Liu et al. · Cancer Cell · 2011 · 2.8K citations · Full text

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

Chao Lü, Patrick S. Ward, Gurpreet S. Kapoor et al. · Nature · 2012 · 2K citations

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IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

Takuya Watanabe, Sumihito Nobusawa, Paul Kleihues et al. · American Journal Of Pathology · 2009 · 1K citations · Full text

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