Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Wei Xu, Hui Yang, Ying Liu, +19

Cancer Cell

Molecular PharmacologyAldehyde DehydrogenaseBiochemistryMedicineMetabolism +2

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

Hui Yang, Yi Liu, Feng Bai, +9

Oncogene

Tumor BiologyTet Gene ExpressionOncogenic AgentMedicineTumor Development +8

WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation

Yiping Wang, Mengtao Xiao, Xiufei Chen, +12

Molecular Cell

Cell RegulationMedicineWt1 Recruits Tet2Gene ExpressionCancer Cell Biology +8

Evaluation of health-related quality of life using EQ-5D in China during the COVID-19 pandemic

Weiwei Ping, Jianzhong Zheng, Xiaohong Niu, +4

PLoS ONE

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Siyun Kuang, Jun Zheng, Hui Yang, +7

Proceedings of the National Academy of Sciences

<scp>SIRT</scp> 3‐dependent <scp>GOT</scp> 2 acetylation status affects the malate–aspartate <scp>NADH</scp> shuttle activity and pancreatic tumor growth

Hui Yang, Lisha Zhou, Qian Shi, +9

The EMBO Journal

Pancreatic CancerMedicinePathologyAcetylation StatusCancer Biology +6

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 <b>α</b> –Dependent Glycolysis

Guangwei Liu, Yujing Bi, Bo Shen, +8

Cancer Research

Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4 + T Cells

Yu Wang, Yujing Bi, Xi Chen, +9

Immunity

ChromatinAutoimmune DiseaseChromatin RemodelingImmune Cell DevelopmentMedicine +10

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Leilei Chen, Carmen Morcelle, Zhou‐Li Cheng, +34

Nature Cell Biology

InflammationInflammatory ResponsesImmunologyReactive Oxygen SpecieGene Expression +3

Clinical features and outcomes of pregnant women suspected of coronavirus disease 2019

Hui Yang, Guoqiang Sun, Fei Tang, +6

Journal of Infection

Coronavirus Disease 2019Viral DiagnosticsGlobal HealthCovid-19 PandemicClinical Epidemiology +10