Journal of the American Chemical Society · 2002 · 69 citations · 11 references
PharmacyBiochemistryMolecular BiologyApoptosisCombinatorial ChemistryDrug DiscoveryBiologics DiscoveryChemical Library DesignCombinatorial SynthesisLibrary ConstructionLibrary DesignLibrary ScreeningApoptosis InductionBiological CharacterizationCeramide StructureCombinatorial Library ConstructionCombinatorial Library DesignCombinatorial Library SynthesisNf-kappa B-mediated Anti-apoptotic SignalingNf-κb Signaling
A facile synthesis of a combinatorial ceramide library and their activities in the NF-kappaB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-kappaB activating molecule was discovered among ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.
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