Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene · 1989 · 7.5K citations

Life Sciences, Biotechnology, Molecular Biology +10

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Laura S. Schmidt, Fuh-Mei Duh, Fan Chen et al. · Nature Genetics · 1997 · 1.5K citations

Medicine, Genetics, Oncology +17

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

Robert M.W. Hofstra, Rudy M. Landsvater, Isabella Ceccherini et al. · Nature · 1994 · 1.2K citations

Medicine, Genetics, Oncology +16

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.

H Nagata, A S Worobec, Chang Kyu Oh et al. · Proceedings of the National Academy of Sciences · 1995 · 880 citations

Life Sciences, Genetics, Hematology +16

Activation of <i>RET</i> as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

Massimo Santoro, Francesca Carlomagno, Alfredo Romano et al. · Science · 1995 · 838 citations

Medicine, Genetics, Molecular Genetics +17