Concepedia

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

Steven P. Tanis, Michael Plewe, Ted W. Johnson, Scott L. Butler, Deepak Dalvie, Dorothy M. DeLisle, Klaus Dress, Qiyue Hu, Buwen Huang, Jon Kuehler,

Bioorganic & Medicinal Chemistry Letters · 2010 · 23 citations · 16 references

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16

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli et al. · Journal of Medicinal Chemistry · 2008 · 634 citations · Full text

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Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137)

Kazuya Shimura, Eiichi Kodama, Yasuko Sakagami et al. · Journal of Virology · 2007 · 344 citations · Full text

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Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance.

A Rane, G. Wilkinson, David G. Shand · Journal of Pharmacology and Experimental Therapeutics · 1977 · 328 citations

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Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

Natilie Hosea, Wendy T. Collard, Susan Cole et al. · The Journal of Clinical Pharmacology · 2009 · 297 citations

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Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

Thomas Ryckmans, Martin P. Edwards, Val A. Horne et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 269 citations · Full text

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