Jon Kuehler

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of <i>MTAP</i> -Deleted Cancers

Christopher R. Smith, Ruth Aranda, Thomas P. Bobinski et al. · Journal of Medicinal Chemistry · 2022 · 151 citations · Full text

Pharmacy, Oncology, Pharmacology +15

Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

John M. Ketcham, Jacob R. Haling, Shilpi Khare et al. · Journal of Medicinal Chemistry · 2022 · 94 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors

Michael Plewe, Scott L. Butler, Klaus Dress et al. · Journal of Medicinal Chemistry · 2009 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Design and Synthesis of Novel <i>N</i>-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Ted W. Johnson, Steven P. Tanis, Scott L. Butler et al. · Journal of Medicinal Chemistry · 2011 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

Steven P. Tanis, Michael Plewe, Ted W. Johnson et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14