A Kinetic Framework for a Mammalian RNA Polymerase in Vivo

Miroslav Dundr, Urs Hoffmann‐Rohrer, Qiyue Hu, +4

Science

ChromatinSystems BiologyEngineeringMammalian Rna PolymeraseVivo Microscopy +12

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

David C. Pryde, Deepak Dalvie, Qiyue Hu, +3

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmaceutical ChemistryRedox BiologyOxidative StressMolecular Pharmacology +14

Rrn3 Phosphorylation Is a Regulatory Checkpoint for Ribosome Biogenesis

Alice Cavanaugh, Iwona Hirschler‐Laszkiewicz, Qiyue Hu, +4

Journal of Biological Chemistry

Comparing Techniques of Measuring Tumor Hypoxia in Different Murine Tumors: Eppendorf pO 2 Histograph, [ 3 H]Misonidazole Binding and Paired Survival Assay

Mary-Claire Kavanagh, A. Sun, Qiyue Hu, +1

Radiation Research

Tumor ActivityTumor BiologyEndocrine OncologyTumor HypoxiaTransplantable Murine Tumors +13

Systematic Structure Modifications of Imidazo[1,2-<i>a</i>]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)

Angelica Linton, Ping Kang, Martha A. Ornelas, +5

Journal of Medicinal Chemistry

Androgen ReceptorBioorganic ChemistryMolecular BiologyPharmacotherapyChemical Biology +20

Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design

Hengmiao Cheng, Shubha Bagrodia, Simon Bailey, +9

MedChemComm

Drug TargetTumor BiologyDrug DesignAnti-cancer AgentCompound 1 +14

Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes

Amanda Mathis, Arlene S. Bridges, Mohamed A. Ismail, +12

Antimicrobial Agents and Chemotherapy

Medicinal ChemistryHuman African TrypanosomiasisBioorganic ChemistryDna BindingBiochemistry +13

Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis

Elen Mello de Souza, Amélie Lansiaux, Christian Bailly, +6

Biochemical Pharmacology

Trypanosoma CruziBiochemistryAntiparasitic AgentMedicineParasitic Protozoa +8

Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.

Amélie Lansiaux, Farial A. Tanious, Zohar Mishal, +7

PubMed

Drug TargetTumor CellsPeptide ScienceDiphenylfuran DerivativesDiphenylfuran Diamidines +19

Pfizer Global Virtual Library (PGVL): A Chemistry Design Tool Powered by Experimentally Validated Parallel Synthesis Information

Qiyue Hu, Zhengwei Peng, Scott C. Sutton, +10

ACS Combinatorial Science

Combinatorial ChemistryEngineeringMolecular BiologyComputational ChemistryMolecular Design +16