Buwen Huang

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (<i>R</i>)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (PF-06821497)

Pei‐Pei Kung, Patrick Bingham, Alexei Brooun et al. · Journal of Medicinal Chemistry · 2017 · 125 citations · Full text

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Kevin D. Freeman‐Cook, Robert L. Hoffman, Douglas C. Behenna et al. · Journal of Medicinal Chemistry · 2021 · 112 citations · Full text

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

Pei‐Pei Kung, Buwen Huang, Gang Zhang et al. · Journal of Medicinal Chemistry · 2009 · 73 citations · Full text

Pharmaceutical Science, Chemical Biology, Pharmaceutical Chemistry +16

Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer

Pei‐Pei Kung, Ricardo Martínez, Zhou Zhu et al. · Molecular Cancer Therapeutics · 2014 · 68 citations

Breast Oncology, Cancer Biology, Tumor Biology +18

Discovery of Novel Disaccharide Antibacterial Agents Using a Combinatorial Library Approach

Michael J. Sofia, Nigel M. Allanson, Nicole T. Hatzenbuhler et al. · Journal of Medicinal Chemistry · 1999 · 66 citations

Antibiotic Adjuvant, Altmetric Attention Score, Antimicrobial Chemotherapy +17