Assessing computational tools for the discovery of transcription factor binding sites

Martin Tompa, Nan Li, Timothy L. Bailey, +22

Nature Biotechnology

BioinformaticsSequence MotifComputational ToolsTranscriptional RegulationNatural Sciences +11

p63 protects the female germ line during meiotic arrest

Eun-Kyung Suh, Annie Yang, Arminja N. Kettenbach, +7

Nature

InfertilityDevelopmental BiologyFertilityCell DivisionFemale Infertility +8

Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor–Positive Metastatic Breast Cancer

Nicholas C. Turner, Yuan Liu, Zhou Zhu, +13

Journal of Clinical Oncology

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

Liron Bar‐Peled, Esther K. Kemper, Radu M. Suciu, +17

Cell

MedicineNatural SciencesProteomicsMolecular BiologyCancer Genomics +6

Relationships between p63 Binding, DNA Sequence, Transcription Activity, and Biological Function in Human Cells

Annie Yang, Zhou Zhu, Philipp Kapranov, +4

Molecular Cell

Transcriptional RegulationHuman CellCell RegulationHuman CellsP63 Binding +9

Genomic Landscape of Copy Number Aberrations Enables the Identification of Oncogenic Drivers in Hepatocellular Carcinoma

Kai Wang, Ho Yeong Lim, Stephanie T. Shi, +11

Hepatology

Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

Kevin D. Freeman‐Cook, Robert L. Hoffman, Nichol Miller, +45

Cancer Cell

Tumor BiologyOncologyCdk2/4/6 InhibitorMedicineTumor Cell Cycle +8

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

Ju‐Xian Song, Sandeep Malampati, Yu Zeng, +12

Aging Cell

Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models

Xu‐Xu Zhuang, Sheng-Fang Wang, Yuan Tan, +10

Cell Death and Disease

Disease ModelsNeurodegenerative DiseasesPharmacological EnhancementCell AutophagyMedicine +11

Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo

Zhou Zhu, Qiang Zhang, Zhiyuan Yu, +6

Glia