An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Ekaterina V. Vinogradova, Xiaoyu Zhang, David Remillard, +25

Cell

Electrophile-cysteine InteractionsSignal TransductionBiochemistryCell InteractionCell Trafficking +8

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

Liron Bar‐Peled, Esther K. Kemper, Radu M. Suciu, +17

Cell

MedicineNatural SciencesProteomicsMolecular BiologyCancer Genomics +6

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Nalle Pentinmikko, Sharif Iqbal, Miyeko Mana, +21

Nature

Developmental BiologyPaneth CellsAged Intestinal EpitheliumDigestive TractGut Barrier +4

A proteome-wide atlas of lysine-reactive chemistry

Mikail E. Abbasov, Madeline E. Kavanagh, Taka-Aki Ichu, +11

Nature Chemistry

Protein ChemistryProteomic TechnologyBiochemistryNatural SciencesLysine-reactive Chemistry +1

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

Ilana Chefetz, Edward Grimley, Kun Yang, +23

Cell Reports

OncologyEndocrine-related CancerMedicineApoptosisGynecology +7

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Jarrett R. Remsberg, Radu M. Suciu, Noemi A. Zambetti, +15

Nature Chemical Biology

Cell SignalingMedicinePathologyCell ProliferationTumor Suppressor +7

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

Claudio Zambaldo, Ekaterina V. Vinogradova, Xiaotian Qi, +12

Journal of the American Chemical Society

Chemical Proteomic Profiling of Human Methyltransferases

Benjamin D. Horning, Radu M. Suciu, Darian A. Ghadiri, +7

Journal of the American Chemical Society

Epigenetic ChangeMolecular BiologyNative Biological SystemsMethyl GroupsChemical Biology +21

Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes

De‐Wei Gao, Ekaterina V. Vinogradova, Sri Krishna Nimmagadda, +5

Journal of the American Chemical Society

Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator

Doğukan Mizrak, N. Sumru Bayın, Jinzhou Yuan, +8

Cell Reports

Cardiac Progenitor CellsCellular NeurobiologyLineage Progression DynamicsSingle Cell SequencingNew Olfactory Bulb +15